· 哈佛大学丹娜法伯癌症研究院成人白血病临床与转化研究主任

· 哈佛医学院教授

【专长领域】

· 急性淋巴细胞白血病

· 急性髓系白血病

· 慢性髓系白血病

· 骨髓增生异常/骨髓增生性疾病

【教育背景】

1993年毕业于阿尔伯爱因斯坦医学院，取得博士学位

1996年于麻省总院完成住院医培训

1999年于丹娜法伯癌症研究院完成血液/肿瘤学专科培训

【从医荣誉】(摘选)

2014，2015，2018年荣获“最富同情心医生”称号

2018年荣获“准时医生”奖

2012，2018年荣获“患者选择”奖

【研究方向】

· CAR-T

· 白血病

· 肥大细胞增多症

· 骨髓增生异常综合征

· 骨髓增生性疾病

【学术著作】(摘选)

1. Cortes JE, Kim DW, Pinilla-Ibarz J, le Coutre PD, Paquette R, Chuah C, Nicolini FE, Apperley JF, Khoury HJ, Talpaz M, DeAngelo DJ, Abruzzese E, Rea D, Baccarani M, Müller MC, Gambacorti-Passerini C, Lustgarten S, Rivera VM, Haluska FG, Guilhot F, Deininger MW, Hochhaus A, Hughes TP, Shah NP, Kantarjian HM. Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial. Blood. 2018 Mar 22.

普纳替尼在费城染色体阳性白血病中的疗效和安全性：2期PACE试验的最终5年结果

2. Wagner FF, Benajiba L, Campbell AJ, We?wer M, Sacher JR, Gale JP, Ross L, Puissant A, Alexe G, Conway A, Back M, Pikman Y, Galinsky I, DeAngelo DJ, Stone RM, Kaya T, Shi X, Robers MB, Machleidt T, Wilkinson J, Hermine O, Kung A, Stein AJ, Lakshminarasimhan D, Hemann MT, Scolnick E, Zhang YL, Pan JQ, Stegmaier K, Holson EB. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 07; 10(431).

利用糖原合成酶激酶3中的Asp-Glu“开关”来研发用于急性骨髓性白血病的旁系同源物选择性抑制剂

3. Luskin MR, DeAngelo DJ. How to treat chronic myeloid leukemia (CML) in older adults. J Geriatr Oncol. 2018 Feb 18.

如何治疗慢性髓系白血病老年患者

4. Siegel SE, Stock W, Johnson RH, Advani A, Muffly L, Douer D, Reed D, Lewis M, Freyer DR, Shah B, Luger S, Hayes-Lattin B, Jaboin JJ, Coccia PF, DeAngelo DJ, Seibel N, Bleyer A. Pediatric-Inspired Treatment Regimens for Adolescents and Young Adults With Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Review. JAMA Oncol. 2018 Feb 15.

受儿童治疗方案费城染色体阴性急性淋巴细胞白血病的青少年和年轻成人

5. Grace RF, DeAngelo DJ, Stevenson KE, Neuberg D, Sallan SE, Mourad YRA, Bergeron J, Seftel MD, Kokulis C, Connors JM. The use of prophylactic anticoagulation during induction and consolidation chemotherapy in adults with acute lymphoblastic leukemia. J Thromb Thrombolysis. 2018 Feb; 45(2):306-314.

在急性淋巴细胞白血病成人患者诱导和巩固化疗期间使用预防性抗凝治疗

6. Stein EM, Walter RB, Erba HP, Fathi AT, Advani AS, Lancet JE, Ravandi F, Kovacsovics T, DeAngelo DJ, Bixby D, Faderl S, Jillella AP, Ho PA, O'Meara MM, Zhao B, Biddle-Snead C, Stein AS. A phase 1 trial of vadastuximab talirine as monotherapy in patients with CD33-positive acute myeloid leukemia. Blood. 2018 Jan 25; 131(4):387-396.

Vadastuximab talirine单药治疗CD33阳性急性髓系白血病的Ⅰ期试验

7. DeAngelo DJ, Brunner AM, Werner L, Avigan D, Fathi AT, Sperling AS, Washington A, Stroopinsky D, Rosenblatt J, McMasters M, Luptakova K, Wadleigh M, Steensma DP, Hobbs GS, Attar EC, Amrein PC, Ebert BL, Stone RM, Ballen KK. A phase I study of lenalidomide plus chemotherapy with mitoxantrone, etoposide, and cytarabine for the reinduction of patients with acute myeloid leukemia. Am J Hematol. 2018 Feb; 93(2):254-261.

来那度胺联合米托蒽醌+依托泊苷+阿糖胞苷化疗用于急性髓细胞白血病患者的再次诱导治疗的I期试验