· 哈佛医学院丹娜法伯癌症研究院胃肠癌症中心临床研究主任

· 哈佛医学院助理教授

【专长领域】

· 肛门癌

· 胆管癌

· 结肠癌

· 食管癌

· 胆囊癌

· 胃肠道良性肿瘤

· 肝癌

· 神经内分泌良性肿瘤

· 胰腺癌

· 直肠癌

· 胃癌

【教育背景】

2001年毕业于宾夕法尼亚大学医学院，获得博士学位

2004年于加州大学旧金山分校完成实习和内科学住院医培训

2008年于麻省总院完成血液学专科培训，于丹娜法伯癌症研究中心完成血液/肿瘤学专科培训

【研究方向】

胃肠肿瘤的新疗法

寻找影响结直肠癌患者生存期的分子预测因子

【学术著作】(摘选)

Phase II study of everolimus in patients with metastatic colorectal adenocarcinoma previously treated with bevacizumab-, fluoropyrimidine-, oxaliplatin-, and irinotecan-based regimens. Ng K, Tabernero J, Hwang J, Bajetta E, Sharma S, Del Prete SA, Arrowsmith ER, Ryan DP, Sedova M, Jin J, Malek K, Fuchs CS. Clin Cancer Res. 2013 Jul 15;19(14):3987-95. doi: 10.1158/1078-0432.CCR-13-0027. Epub 2013 Jun 6.

先前用贝伐单抗，氟嘧啶，奥沙利铂和伊立替康为基础方案治疗的转移性结直肠腺癌患者使用依维莫司治疗的Ⅱ期试验

Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer. Ng K, Wolpin BM, Meyerhardt JA, Wu K, Chan AT, Hollis BW, Giovannucci EL, Stampfer MJ, Willett WC, Fuchs CS. Br J Cancer. 2009 Sep 15;101(6):916-23. doi: 10.1038/sj.bjc.6605262. Epub 2009 Aug 18. Erratum in: Br J Cancer. 2010 Mar 16;102(6):1079.

关于结直肠癌患者预测因子维生素D状态和生存期关系的前瞻性研究

Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance). Fadelu T, Zhang S, Niedzwiecki D, Ye X, Saltz LB, Mayer RJ, Mowat RB, Whittom R, Hantel A, Benson AB, Atienza DM, Messino M, Kindler HL, Venook A, Ogino S, Ng K, Wu K, Willett W, Giovannucci E, Meyerhardt J, Bao Y, Fuchs CS. J Clin Oncol. 2018 Apr 10;36(11):1112-1120. doi: 10.1200/JCO.2017.75.5413. Epub 2018 Feb 28.

III期结肠癌患者食用坚果和生存期的关系

Prediagnosis Use of Statins Associates With Increased Survival Times of Patients With Pancreatic Cancer. Hamada T, Khalaf N, Yuan C, Morales-Oyarvide V, Babic A, Nowak JA, Qian ZR, Ng K, Rubinson DA, Kraft P, Giovannucci EL, Stampfer MJ, Fuchs CS, Ogino S, Wolpin BM. Clin Gastroenterol Hepatol. 2018 Feb 21. pii: S1542-3565(18)30167-8. doi: 10.1016/j.cgh.2018.02.022.

胰腺癌患者早期诊断使用他汀类药物可增加患者的生存时间

Regular Use of Aspirin or Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs Is Not Associated With Risk of Incident Pancreatic Cancer in Two Large Cohort Studies. Khalaf N, Yuan C, Hamada T, Cao Y, Babic A, Morales-Oyarvide V, Kraft P, Ng K, Giovannucci E, Ogino S, Stampfer M, Cochrane BB, Manson JE, Clish CB, Chan AT, Fuchs CS, Wolpin BM. Gastroenterology. 2018 Apr;154(5):1380-1390.e5. doi: 10.1053/j.gastro.2017.12.001. Epub 2017 Dec 8.

在两项大型队列研究中发现定期使用阿司匹林或非阿司匹林非甾体类抗炎药物与胰腺癌发生风险无关